| Round 1 (22) | Round 2 (23) |
| Atlético-MG - Atlético Madrid | Ajax - Fiorentina |
| Auxerre - Lyon | Atlético Madrid - B.Mönchengladbach |
| B.Mönchengladbach - Ajax | Blackburn Rovers - Fenerbahçe |
| Dinamo Zagreb - Kaiserslautern | Deportivo - Metz |
| FK Austria - Blackburn Rovers | Kaiserslautern - Auxerre |
| Fenerbahçe - Valencia | Lyon - Udinese |
| Fiorentina - TSG Hoffenheim | Middlesbrough - Dinamo Zagreb |
| Metz - Panathinaikos | Panathinaikos - Wisla Kraków |
| Real Oviedo - Middlesbrough | Sevilla - Real Oviedo |
| Udinese - Deportivo | TSG Hoffenheim - Atlético-MG |
| Wisla Kraków - Sevilla | Valencia - FK Austria |
|
| Round 3 (24) | Round 4 (25) |
| Atlético-MG - Panathinaikos | Ajax - Auxerre |
| Auxerre - Middlesbrough | Atlético Madrid - Fiorentina |
| B.Mönchengladbach - Lyon | Blackburn Rovers - Atlético-MG |
| Dinamo Zagreb - Sevilla | Deportivo - FK Austria |
| FK Austria - Atlético Madrid | Kaiserslautern - Wisla Kraków |
| Fenerbahçe - Deportivo | Lyon - Real Oviedo |
| Fiorentina - Valencia | Middlesbrough - Metz |
| Metz - TSG Hoffenheim | Panathinaikos - B.Mönchengladbach |
| Real Oviedo - Blackburn Rovers | Sevilla - Udinese |
| Udinese - Kaiserslautern | TSG Hoffenheim - Fenerbahçe |
| Wisla Kraków - Ajax | Valencia - Dinamo Zagreb |
|
| Round 5 (26) | Round 6 (27) |
| Atlético-MG - Deportivo | Atlético Madrid - Blackburn Rovers |
| Auxerre - Blackburn Rovers | Auxerre - Dinamo Zagreb |
| B.Mönchengladbach - Kaiserslautern | B.Mönchengladbach - Udinese |
| Dinamo Zagreb - TSG Hoffenheim | Deportivo - TSG Hoffenheim |
| FK Austria - Panathinaikos | Fenerbahçe - Atlético-MG |
| Fenerbahçe - Ajax | Fiorentina - FK Austria |
| Fiorentina - Sevilla | Kaiserslautern - Sevilla |
| Metz - Lyon | Middlesbrough - Lyon |
| Real Oviedo - Atlético Madrid | Panathinaikos - Ajax |
| Udinese - Middlesbrough | Real Oviedo - Valencia |
| Wisla Kraków - Valencia | Wisla Kraków - Metz |
|
| Round 7 (28) | Round 8 (29) |
| Ajax - Deportivo | Atlético Madrid - Lyon |
| Atlético-MG - Fiorentina | Blackburn Rovers - Valencia |
| Blackburn Rovers - Panathinaikos | Deportivo - Panathinaikos |
| Dinamo Zagreb - B.Mönchengladbach | FK Austria - Udinese |
| FK Austria - Fenerbahçe | Fenerbahçe - Fiorentina |
| Lyon - Kaiserslautern | Metz - B.Mönchengladbach |
| Metz - Auxerre | Middlesbrough - Kaiserslautern |
| Sevilla - Middlesbrough | Real Oviedo - Dinamo Zagreb |
| TSG Hoffenheim - Real Oviedo | Sevilla - Atlético-MG |
| Udinese - Wisla Kraków | TSG Hoffenheim - Ajax |
| Valencia - Atlético Madrid | Wisla Kraków - Auxerre |
|
| Round 9 (30) | Round 10 (31) |
| Ajax - Blackburn Rovers | Ajax - Lyon |
| Atlético-MG - FK Austria | Atlético Madrid - Middlesbrough |
| Auxerre - Real Oviedo | Atlético-MG - Wisla Kraków |
| B.Mönchengladbach - Wisla Kraków | Blackburn Rovers - Kaiserslautern |
| Dinamo Zagreb - Fenerbahçe | Deportivo - Real Oviedo |
| Fiorentina - Deportivo | FK Austria - Auxerre |
| Kaiserslautern - Atlético Madrid | Fenerbahçe - Metz |
| Lyon - Sevilla | Fiorentina - B.Mönchengladbach |
| Panathinaikos - TSG Hoffenheim | Panathinaikos - Dinamo Zagreb |
| Udinese - Metz | TSG Hoffenheim - Sevilla |
| Valencia - Middlesbrough | Valencia - Udinese |
|
| Round 11 (32) | Round 12 (33) |
| Auxerre - TSG Hoffenheim | Auxerre - Valencia |
| B.Mönchengladbach - Atlético-MG | B.Mönchengladbach - Fenerbahçe |
| Dinamo Zagreb - Deportivo | Dinamo Zagreb - Atlético Madrid |
| Kaiserslautern - Ajax | Kaiserslautern - TSG Hoffenheim |
| Lyon - Panathinaikos | Lyon - Deportivo |
| Metz - Valencia | Metz - Blackburn Rovers |
| Middlesbrough - Fenerbahçe | Middlesbrough - FK Austria |
| Real Oviedo - FK Austria | Real Oviedo - Panathinaikos |
| Sevilla - Blackburn Rovers | Sevilla - Ajax |
| Udinese - Fiorentina | Udinese - Atlético-MG |
| Wisla Kraków - Atlético Madrid | Wisla Kraków - Fiorentina |
|
| Round 13 (34) | Round 14 (35) |
| Ajax - Dinamo Zagreb | Auxerre - Panathinaikos |
| Atlético Madrid - Metz | B.Mönchengladbach - TSG Hoffenheim |
| Atlético-MG - Real Oviedo | Dinamo Zagreb - Fiorentina |
| Blackburn Rovers - B.Mönchengladbach | Kaiserslautern - Valencia |
| Deportivo - Kaiserslautern | Lyon - FK Austria |
| FK Austria - Wisla Kraków | Metz - Atlético-MG |
| Fenerbahçe - Udinese | Middlesbrough - Ajax |
| Fiorentina - Auxerre | Real Oviedo - Fenerbahçe |
| Panathinaikos - Middlesbrough | Sevilla - Deportivo |
| TSG Hoffenheim - Lyon | Udinese - Atlético Madrid |
| Valencia - Sevilla | Wisla Kraków - Blackburn Rovers |
|
| Round 15 (36) | Round 16 (37) |
| Ajax - Real Oviedo | Auxerre - Atlético Madrid |
| Atlético Madrid - Sevilla | B.Mönchengladbach - Valencia |
| Atlético-MG - Dinamo Zagreb | Dinamo Zagreb - Blackburn Rovers |
| Blackburn Rovers - Udinese | Kaiserslautern - Fenerbahçe |
| Deportivo - Auxerre | Lyon - Atlético-MG |
| FK Austria - B.Mönchengladbach | Metz - FK Austria |
| Fenerbahçe - Wisla Kraków | Middlesbrough - Deportivo |
| Fiorentina - Metz | Real Oviedo - Fiorentina |
| Panathinaikos - Kaiserslautern | Sevilla - Panathinaikos |
| TSG Hoffenheim - Middlesbrough | Udinese - Ajax |
| Valencia - Lyon | Wisla Kraków - TSG Hoffenheim |
|
| Round 17 (38) | Round 18 (39) |
| Atlético-MG - Valencia | Atlético Madrid - Panathinaikos |
| Auxerre - Sevilla | Atlético-MG - Ajax |
| B.Mönchengladbach - Middlesbrough | B.Mönchengladbach - Real Oviedo |
| Dinamo Zagreb - Lyon | Blackburn Rovers - Middlesbrough |
| FK Austria - TSG Hoffenheim | FK Austria - Dinamo Zagreb |
| Fenerbahçe - Atlético Madrid | Fenerbahçe - Auxerre |
| Fiorentina - Blackburn Rovers | Fiorentina - Kaiserslautern |
| Metz - Ajax | Metz - Sevilla |
| Real Oviedo - Kaiserslautern | Udinese - TSG Hoffenheim |
| Udinese - Panathinaikos | Valencia - Deportivo |
| Wisla Kraków - Deportivo | Wisla Kraków - Lyon |
|
| Round 19 (40) | Round 20 (41) |
| Ajax - FK Austria | Atlético Madrid - Ajax |
| Auxerre - Atlético-MG | Atlético-MG - Kaiserslautern |
| Deportivo - B.Mönchengladbach | B.Mönchengladbach - Auxerre |
| Dinamo Zagreb - Udinese | Blackburn Rovers - Deportivo |
| Kaiserslautern - Metz | FK Austria - Sevilla |
| Lyon - Blackburn Rovers | Fenerbahçe - Lyon |
| Middlesbrough - Fiorentina | Fiorentina - Panathinaikos |
| Panathinaikos - Valencia | Metz - Dinamo Zagreb |
| Real Oviedo - Wisla Kraków | Udinese - Real Oviedo |
| Sevilla - Fenerbahçe | Valencia - TSG Hoffenheim |
| TSG Hoffenheim - Atlético Madrid | Wisla Kraków - Middlesbrough |
|
| Round 21 (42) |
| Ajax - Valencia |
| Auxerre - Udinese |
| Deportivo - Atlético Madrid |
| Dinamo Zagreb - Wisla Kraków |
| Kaiserslautern - FK Austria |
| Lyon - Fiorentina |
| Middlesbrough - Atlético-MG |
| Panathinaikos - Fenerbahçe |
| Real Oviedo - Metz |
| Sevilla - B.Mönchengladbach |
| TSG Hoffenheim - Blackburn Rovers |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Atlético Madrid - Deportivo, Atlético-MG - Middlesbrough etc. |