| Round 1 (22) | Round 2 (23) |
| Anderlecht - Zaragoza | Atlético-MG - Wisla Kraków |
| Athletic Bilbao - Panathinaikos | Auxerre - Valencia |
| Atlético Madrid - São Paulo | B.Mönchengladbach - Osasuna |
| Blackburn Rovers - Independiente | Deportivo - Blackburn Rovers |
| FK Austria - B.Mönchengladbach | Dinamo Zagreb - Atlético Madrid |
| Kaiserslautern - Deportivo | Independiente - Anderlecht |
| Lazio - Atlético-MG | Middlesbrough - Athletic Bilbao |
| Osasuna - TSG Hoffenheim | Panathinaikos - Kaiserslautern |
| PSV - Auxerre | São Paulo - PSV |
| Valencia - Dinamo Zagreb | TSG Hoffenheim - FK Austria |
| Wisla Kraków - Middlesbrough | Zaragoza - Lazio |
|
| Round 3 (24) | Round 4 (25) |
| Anderlecht - Dinamo Zagreb | Atlético-MG - Blackburn Rovers |
| Athletic Bilbao - Atlético-MG | Auxerre - Kaiserslautern |
| Atlético Madrid - Zaragoza | B.Mönchengladbach - Atlético Madrid |
| Blackburn Rovers - Panathinaikos | Deportivo - Wisla Kraków |
| FK Austria - São Paulo | Dinamo Zagreb - Osasuna |
| Kaiserslautern - Middlesbrough | Independiente - FK Austria |
| Lazio - Auxerre | Middlesbrough - Anderlecht |
| Osasuna - Independiente | Panathinaikos - Lazio |
| PSV - Deportivo | São Paulo - Valencia |
| Valencia - TSG Hoffenheim | TSG Hoffenheim - Athletic Bilbao |
| Wisla Kraków - B.Mönchengladbach | Zaragoza - PSV |
|
| Round 5 (26) | Round 6 (27) |
| Anderlecht - Deportivo | Independiente - Dinamo Zagreb |
| Athletic Bilbao - Dinamo Zagreb | Kaiserslautern - Athletic Bilbao |
| Atlético Madrid - Independiente | Lazio - Anderlecht |
| Blackburn Rovers - Middlesbrough | Middlesbrough - Deportivo |
| FK Austria - Zaragoza | Osasuna - Atlético Madrid |
| Kaiserslautern - B.Mönchengladbach | PSV - Blackburn Rovers |
| Lazio - TSG Hoffenheim | Panathinaikos - Atlético-MG |
| Osasuna - Auxerre | São Paulo - B.Mönchengladbach |
| PSV - Panathinaikos | Valencia - FK Austria |
| Valencia - Atlético-MG | Wisla Kraków - TSG Hoffenheim |
| Wisla Kraków - São Paulo | Zaragoza - Auxerre |
|
| Round 7 (28) | Round 8 (29) |
| Anderlecht - Kaiserslautern | Anderlecht - PSV |
| Athletic Bilbao - PSV | Atlético-MG - Atlético Madrid |
| Atlético Madrid - Valencia | B.Mönchengladbach - TSG Hoffenheim |
| Atlético-MG - Middlesbrough | Dinamo Zagreb - Auxerre |
| Auxerre - Independiente | FK Austria - Blackburn Rovers |
| B.Mönchengladbach - Zaragoza | Independiente - Zaragoza |
| Blackburn Rovers - Lazio | Lazio - Kaiserslautern |
| Deportivo - Panathinaikos | Middlesbrough - Panathinaikos |
| Dinamo Zagreb - Wisla Kraków | Osasuna - Valencia |
| FK Austria - Osasuna | São Paulo - Deportivo |
| TSG Hoffenheim - São Paulo | Wisla Kraków - Athletic Bilbao |
|
| Round 9 (30) | Round 10 (31) |
| Athletic Bilbao - Osasuna | Atlético Madrid - Lazio |
| Atlético Madrid - FK Austria | Auxerre - Deportivo |
| Auxerre - B.Mönchengladbach | B.Mönchengladbach - Panathinaikos |
| Blackburn Rovers - Anderlecht | Dinamo Zagreb - Atlético-MG |
| Deportivo - Atlético-MG | FK Austria - Kaiserslautern |
| Kaiserslautern - Wisla Kraków | Independiente - Wisla Kraków |
| PSV - Lazio | Osasuna - Anderlecht |
| Panathinaikos - São Paulo | São Paulo - Middlesbrough |
| TSG Hoffenheim - Middlesbrough | TSG Hoffenheim - Blackburn Rovers |
| Valencia - Independiente | Valencia - PSV |
| Zaragoza - Dinamo Zagreb | Zaragoza - Athletic Bilbao |
|
| Round 11 (32) | Round 12 (33) |
| Anderlecht - TSG Hoffenheim | Anderlecht - B.Mönchengladbach |
| Athletic Bilbao - Independiente | Athletic Bilbao - São Paulo |
| Atlético-MG - B.Mönchengladbach | Atlético-MG - Auxerre |
| Blackburn Rovers - Valencia | Blackburn Rovers - Atlético Madrid |
| Deportivo - Zaragoza | Deportivo - Independiente |
| Kaiserslautern - Dinamo Zagreb | Kaiserslautern - TSG Hoffenheim |
| Lazio - São Paulo | Lazio - Valencia |
| Middlesbrough - Osasuna | Middlesbrough - FK Austria |
| PSV - Atlético Madrid | PSV - Osasuna |
| Panathinaikos - Auxerre | Panathinaikos - Dinamo Zagreb |
| Wisla Kraków - FK Austria | Wisla Kraków - Zaragoza |
|
| Round 13 (34) | Round 14 (35) |
| Atlético Madrid - Wisla Kraków | Anderlecht - Atlético Madrid |
| Auxerre - Athletic Bilbao | Athletic Bilbao - Valencia |
| B.Mönchengladbach - PSV | Atlético-MG - Independiente |
| Dinamo Zagreb - Deportivo | Blackburn Rovers - São Paulo |
| FK Austria - Lazio | Deportivo - FK Austria |
| Independiente - Panathinaikos | Kaiserslautern - Zaragoza |
| Osasuna - Blackburn Rovers | Lazio - B.Mönchengladbach |
| São Paulo - Anderlecht | Middlesbrough - Auxerre |
| TSG Hoffenheim - Atlético-MG | PSV - Dinamo Zagreb |
| Valencia - Kaiserslautern | Panathinaikos - TSG Hoffenheim |
| Zaragoza - Middlesbrough | Wisla Kraków - Osasuna |
|
| Round 15 (36) | Round 16 (37) |
| Atlético Madrid - Athletic Bilbao | Anderlecht - FK Austria |
| Auxerre - Wisla Kraków | Athletic Bilbao - B.Mönchengladbach |
| B.Mönchengladbach - Blackburn Rovers | Atlético-MG - Zaragoza |
| Dinamo Zagreb - Middlesbrough | Blackburn Rovers - Auxerre |
| FK Austria - PSV | Deportivo - Atlético Madrid |
| Independiente - Kaiserslautern | Kaiserslautern - São Paulo |
| Osasuna - Lazio | Lazio - Dinamo Zagreb |
| São Paulo - Atlético-MG | Middlesbrough - Independiente |
| TSG Hoffenheim - Deportivo | PSV - TSG Hoffenheim |
| Valencia - Anderlecht | Panathinaikos - Osasuna |
| Zaragoza - Panathinaikos | Wisla Kraków - Valencia |
|
| Round 17 (38) | Round 18 (39) |
| Anderlecht - Auxerre | Anderlecht - Atlético-MG |
| Athletic Bilbao - Deportivo | Atlético Madrid - Auxerre |
| Atlético Madrid - TSG Hoffenheim | B.Mönchengladbach - Middlesbrough |
| Blackburn Rovers - Zaragoza | Blackburn Rovers - Dinamo Zagreb |
| FK Austria - Dinamo Zagreb | FK Austria - Athletic Bilbao |
| Kaiserslautern - Atlético-MG | Lazio - Deportivo |
| Lazio - Independiente | Osasuna - Kaiserslautern |
| Osasuna - São Paulo | PSV - Wisla Kraków |
| PSV - Middlesbrough | São Paulo - Zaragoza |
| Valencia - B.Mönchengladbach | TSG Hoffenheim - Independiente |
| Wisla Kraków - Panathinaikos | Valencia - Panathinaikos |
|
| Round 19 (40) | Round 20 (41) |
| Athletic Bilbao - Blackburn Rovers | Anderlecht - Athletic Bilbao |
| Atlético-MG - Osasuna | Atlético Madrid - Panathinaikos |
| Auxerre - FK Austria | B.Mönchengladbach - Independiente |
| Deportivo - B.Mönchengladbach | Blackburn Rovers - Wisla Kraków |
| Dinamo Zagreb - São Paulo | FK Austria - Atlético-MG |
| Independiente - PSV | Lazio - Middlesbrough |
| Kaiserslautern - Atlético Madrid | Osasuna - Deportivo |
| Middlesbrough - Valencia | PSV - Kaiserslautern |
| Panathinaikos - Anderlecht | São Paulo - Auxerre |
| Wisla Kraków - Lazio | TSG Hoffenheim - Dinamo Zagreb |
| Zaragoza - TSG Hoffenheim | Valencia - Zaragoza |
|
| Round 21 (42) |
| Athletic Bilbao - Lazio |
| Atlético-MG - PSV |
| Auxerre - TSG Hoffenheim |
| Deportivo - Valencia |
| Dinamo Zagreb - B.Mönchengladbach |
| Independiente - São Paulo |
| Kaiserslautern - Blackburn Rovers |
| Middlesbrough - Atlético Madrid |
| Panathinaikos - FK Austria |
| Wisla Kraków - Anderlecht |
| Zaragoza - Osasuna |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Anderlecht - Wisla Kraków, Atlético Madrid - Middlesbrough etc. |