| Round 1 (22) | Round 2 (23) |
| Athletic Bilbao - FC Schalke 04 | Anderlecht - Boca Juniors |
| Boca Juniors - Olympiakos | Celta Vigo - Athletic Bilbao |
| Club Brugge - Hertha BSC Berlin | FC Schalke 04 - Grêmio |
| Flamengo - PSV | Feyenoord - Leeds United |
| Grêmio - Celta Vigo | Hertha BSC Berlin - Napoli |
| Leeds United - Anderlecht | Manchester United - West Ham United |
| Lokomotiv - Rosenborg | Monaco - Flamengo |
| Napoli - Monaco | Olympiakos - Lokomotiv |
| Sporting - Spartak | PSV - Club Brugge |
| São Paulo - Manchester United | Rosenborg - Sporting |
| West Ham United - Feyenoord | Spartak - São Paulo |
|
| Round 3 (24) | Round 4 (25) |
| Athletic Bilbao - Olympiakos | Anderlecht - São Paulo |
| Boca Juniors - Feyenoord | Celta Vigo - Club Brugge |
| Club Brugge - Rosenborg | FC Schalke 04 - West Ham United |
| Flamengo - FC Schalke 04 | Feyenoord - Sporting |
| Grêmio - Hertha BSC Berlin | Hertha BSC Berlin - Flamengo |
| Leeds United - Manchester United | Manchester United - Lokomotiv |
| Lokomotiv - PSV | Monaco - Leeds United |
| Napoli - Anderlecht | Olympiakos - Grêmio |
| Sporting - Monaco | PSV - Athletic Bilbao |
| São Paulo - Celta Vigo | Rosenborg - Napoli |
| West Ham United - Spartak | Spartak - Boca Juniors |
|
| Round 5 (26) | Round 6 (27) |
| Athletic Bilbao - Monaco | Athletic Bilbao - Club Brugge |
| Boca Juniors - Manchester United | Feyenoord - Spartak |
| Club Brugge - Olympiakos | Flamengo - Grêmio |
| Flamengo - Spartak | Hertha BSC Berlin - Celta Vigo |
| Grêmio - Rosenborg | Leeds United - West Ham United |
| Leeds United - Celta Vigo | Manchester United - Anderlecht |
| Lokomotiv - Anderlecht | Napoli - Boca Juniors |
| Napoli - Feyenoord | Olympiakos - PSV |
| Sporting - FC Schalke 04 | Rosenborg - Monaco |
| São Paulo - Hertha BSC Berlin | Sporting - Lokomotiv |
| West Ham United - PSV | São Paulo - FC Schalke 04 |
|
| Round 7 (28) | Round 8 (29) |
| Anderlecht - Feyenoord | Athletic Bilbao - Flamengo |
| Boca Juniors - Sporting | Celta Vigo - FC Schalke 04 |
| Celta Vigo - Rosenborg | Grêmio - Boca Juniors |
| Club Brugge - Flamengo | Hertha BSC Berlin - Anderlecht |
| FC Schalke 04 - Hertha BSC Berlin | Lokomotiv - Napoli |
| Grêmio - Athletic Bilbao | Manchester United - Feyenoord |
| Lokomotiv - Leeds United | Olympiakos - Rosenborg |
| Monaco - Olympiakos | PSV - Monaco |
| PSV - São Paulo | Spartak - Club Brugge |
| Spartak - Manchester United | Sporting - Leeds United |
| West Ham United - Napoli | São Paulo - West Ham United |
|
| Round 9 (30) | Round 10 (31) |
| Anderlecht - Spartak | Athletic Bilbao - Lokomotiv |
| Boca Juniors - Lokomotiv | Celta Vigo - Feyenoord |
| Club Brugge - Grêmio | Club Brugge - Sporting |
| FC Schalke 04 - Manchester United | FC Schalke 04 - Boca Juniors |
| Feyenoord - Hertha BSC Berlin | Flamengo - Napoli |
| Flamengo - Olympiakos | Grêmio - Leeds United |
| Leeds United - São Paulo | Hertha BSC Berlin - Manchester United |
| Monaco - Celta Vigo | Monaco - Anderlecht |
| Napoli - Sporting | Olympiakos - São Paulo |
| Rosenborg - PSV | PSV - Spartak |
| West Ham United - Athletic Bilbao | Rosenborg - West Ham United |
|
| Round 11 (32) | Round 12 (33) |
| Anderlecht - Rosenborg | Anderlecht - Olympiakos |
| Boca Juniors - Flamengo | Boca Juniors - Club Brugge |
| Feyenoord - Monaco | Feyenoord - PSV |
| Leeds United - PSV | Leeds United - FC Schalke 04 |
| Lokomotiv - FC Schalke 04 | Lokomotiv - Celta Vigo |
| Manchester United - Athletic Bilbao | Manchester United - Grêmio |
| Napoli - Club Brugge | Napoli - Athletic Bilbao |
| Spartak - Celta Vigo | Spartak - Monaco |
| Sporting - Hertha BSC Berlin | Sporting - Flamengo |
| São Paulo - Grêmio | São Paulo - Rosenborg |
| West Ham United - Olympiakos | West Ham United - Hertha BSC Berlin |
|
| Round 13 (34) | Round 14 (35) |
| Athletic Bilbao - Boca Juniors | Anderlecht - Grêmio |
| Celta Vigo - Napoli | Boca Juniors - Hertha BSC Berlin |
| Club Brugge - São Paulo | Feyenoord - FC Schalke 04 |
| FC Schalke 04 - Spartak | Leeds United - Rosenborg |
| Flamengo - Leeds United | Lokomotiv - Club Brugge |
| Grêmio - Sporting | Manchester United - Monaco |
| Hertha BSC Berlin - Lokomotiv | Napoli - PSV |
| Monaco - West Ham United | Spartak - Olympiakos |
| Olympiakos - Feyenoord | Sporting - Celta Vigo |
| PSV - Anderlecht | São Paulo - Athletic Bilbao |
| Rosenborg - Manchester United | West Ham United - Flamengo |
|
| Round 15 (36) | Round 16 (37) |
| Athletic Bilbao - Sporting | Anderlecht - Club Brugge |
| Celta Vigo - Boca Juniors | Boca Juniors - Monaco |
| Club Brugge - West Ham United | Feyenoord - Athletic Bilbao |
| FC Schalke 04 - Anderlecht | Leeds United - Hertha BSC Berlin |
| Flamengo - Lokomotiv | Lokomotiv - Grêmio |
| Grêmio - Napoli | Manchester United - Olympiakos |
| Hertha BSC Berlin - Spartak | Napoli - FC Schalke 04 |
| Monaco - São Paulo | Spartak - Rosenborg |
| Olympiakos - Leeds United | Sporting - PSV |
| PSV - Manchester United | São Paulo - Flamengo |
| Rosenborg - Feyenoord | West Ham United - Celta Vigo |
|
| Round 17 (38) | Round 18 (39) |
| Athletic Bilbao - Hertha BSC Berlin | Athletic Bilbao - Leeds United |
| Boca Juniors - Rosenborg | Boca Juniors - PSV |
| Club Brugge - FC Schalke 04 | Celta Vigo - Manchester United |
| Flamengo - Celta Vigo | Club Brugge - Monaco |
| Grêmio - PSV | FC Schalke 04 - Olympiakos |
| Leeds United - Spartak | Flamengo - Feyenoord |
| Lokomotiv - Monaco | Grêmio - West Ham United |
| Napoli - Manchester United | Hertha BSC Berlin - Rosenborg |
| Sporting - Olympiakos | Lokomotiv - Spartak |
| São Paulo - Feyenoord | Napoli - São Paulo |
| West Ham United - Anderlecht | Sporting - Anderlecht |
|
| Round 19 (40) | Round 20 (41) |
| Anderlecht - Celta Vigo | Athletic Bilbao - Anderlecht |
| Feyenoord - Lokomotiv | Boca Juniors - São Paulo |
| Leeds United - Club Brugge | Celta Vigo - Olympiakos |
| Manchester United - Flamengo | Club Brugge - Feyenoord |
| Monaco - Grêmio | FC Schalke 04 - PSV |
| Olympiakos - Napoli | Flamengo - Rosenborg |
| PSV - Hertha BSC Berlin | Grêmio - Spartak |
| Rosenborg - FC Schalke 04 | Hertha BSC Berlin - Monaco |
| Spartak - Athletic Bilbao | Lokomotiv - West Ham United |
| São Paulo - Sporting | Napoli - Leeds United |
| West Ham United - Boca Juniors | Sporting - Manchester United |
|
| Round 21 (42) |
| Anderlecht - Flamengo |
| Feyenoord - Grêmio |
| Leeds United - Boca Juniors |
| Manchester United - Club Brugge |
| Monaco - FC Schalke 04 |
| Olympiakos - Hertha BSC Berlin |
| PSV - Celta Vigo |
| Rosenborg - Athletic Bilbao |
| Spartak - Napoli |
| São Paulo - Lokomotiv |
| West Ham United - Sporting |
League rounds 22-42 (in brackets) are the respective return ties of rounds 1-21 above,
ie. round 42 is Athletic Bilbao - Rosenborg, Boca Juniors - Leeds United etc. |